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Suture techniques during laparoscopic and robot-assisted partial nephrectomy: a systematic review and quantitative synthesis of peri-operative outcomes

  • Riccardo Bertolo 1,
  • Riccardo Campi 2,
  • Tobias Klatte 3,
  • Maximilian C. Kriegmair 4,
  • Maria Carmen Mir 5,
  • Idir Ouzaid 6,
  • Maciej Salagierski 7,
  • Sam Bhayani 8,
  • Inderbir Gill 9,
  • Jihad Kaouk 1,
  • Umberto Capitanio 11
1 Department of Urology, Cleveland Clinic Foundation, Cleveland, OH, USA 2 Department of Urology, University of Florence, Florence, Italy 3 Department of Urology, Royal Bournemouth and Christchurch Hospitals, Bournemouth, UK 4 Department of Urology, University Medical Centre Mannheim, Mannheim, Germany 5 Department of Urology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain 6 Department of Urology, Bichat Hospital, APHP, Paris Diderot University, Paris, France 7 Urology Department, Faculty of Medicine and Health Sciences, University of Zielona Góra, Zielona Góra, Poland 8 Division of Urology, Washington University School of Medicine, St Louis, MO, USA 9 Keck School of Medicine, USC Institute of Urology, University of Southern California, Los Angeles, CA, USA 10 Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 11 Department of Urology, San Raffaele Scientific Institute, Milan, Italy 12 Division of Experimental Oncology/Unit of Urology, URI, IRCCS San Raffaele Hospital, Milan, Italy

Publication: BJU Int. 2018 Sep 14

DOI: 10.1111/bju.14537

Objective:

To summarize the available evidence on renorrhaphy techniques and to assess their impact on peri-operative outcomes after minimally invasive partial nephrectomy (MIPN).

Materials and methods:

A systematic review of the literature was performed in January 2018 without time restrictions, using MEDLINE, Cochrane and Web of Science databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement recommendations. Studies providing sufficient details on renorrhaphy techniques during laparoscopic or robot-assisted partial nephrectomy and comparative studies focused on peri-operative outcomes were included in qualitative and quantitative analyses, respectively.

Results:

Overall, 67 and 19 studies were included in the qualitative and quantitative analyses, respectively. The overall quality of evidence was low. Specific tumour features (i.e. size, hilar location, anatomical complexity, nearness to renal sinus and/or urinary collecting system), surgeon’s experience, robot-assisted technology, as well as the aim of reducing warm ischaemia time and the amount of devascularized renal parenchyma preserved represented the key factors driving the evolution of the renorrhaphy techniques during MIPN over the past decade. Quantitative synthesis showed that running suture was associated with shorter operating and ischaemia time, and lower postoperative complication and transfusion rates than interrupted suture. Barbed suture had lower operating and ischaemia time and less blood loss than non-barbed suture. The single-layer suture technique was associated with shorter operating and ischaemia time than the double-layer technique. No comparisons were possible concerning renal functional outcomes because of non-homogeneous data reporting.

Conclusions:

Renorrhaphy techniques significantly evolved over the years, improving outcomes. Running suture, particularly using barbed wires, shortened the operating and ischaemia times. A further advantage could derive from avoiding a double-layer suture.

Commented by Dr. Riccardo Bertolo

Precision of tumor excision and renorrhaphy affect the amount of vascularized parenchyma preserved during partial nephrectomy and thus the ultimate renal function.

Current knowledge on renorrhaphy techniques is sparse with no consensus on the best approach.

We summarized the available evidence on renorrhaphy techniques and assessed their impact on perioperative outcomes after minimally-invasive partial nephrectomy.

The systematic review and pooled analysis of the literature showed that running suture, particularly using barbed wires, shorten the operative and the ischemia time.

A further advantage could derive from avoiding a double-layer suture.